Protein Details: Voltage-gated sodium channel subunit beta-3

Protein ID

ICDB_Pro_1591

Protein Name

Voltage-gated sodium channel subunit beta-3

Gene Name

SCN3B; KIAA1158

Organism

Homo sapiens (Human)

Length

215 amino acids

AlphaFoldDB

AF-Q9NY72-F1-model_v4.pdb

Function

Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).

Sequence

MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE

PDB Structures

4L1D 7TJ8 7TJ9

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Brugada Syndrome 7 and Familial Atrial Fibrillation

Location

central neurons; adrenal gland; kidney; peripheral neurons

DOI ID

10.1073/pnas.030362197; 10.1126/science.1133427

RefSeq

NP_001035241.1; NP_060870.1; XP_011541199.1